Cayo Santa Maria is a small island of 13 km in length and 2 km wide and is located in the northeast part of the central province of Villa Clara, in the Jardines del Rey archipelago; at 10 km from the local airport of Las Brujas, at 50 km from Caibarien city and at 116 km from the "Abel Santamaria" Santa Clara's city International Airport.

Cayo Santa Maria offers 11 km of fabulous top quality beaches. To reach the Cayo, you will take a 48 km causeway that connects with Caibarien.

This cay is part of the Jardines del Rey archipelago and is located at 60 km from Villa Clara, a city of high cultural and historical value and where lie the Memorial that renders tribute to the "guerrillero" Ernesto Che Guevara and his fellow companions and at 355 km from Havana.